The Matrix Metalloproteinases

The Matrix Metalloproteinases, Volume 60 in The Enzymes series, explores recent advances in the study of matrix metalloproteinases (MMPs), a critical family of enzymes involved in extracellular matrix remodeling and numerous physiological and pathological processes. This volume presents a comprehensive collection of chapters covering key aspects of MMP biology, including their structure, function, regulation, and detection through activity-based probes.Chapters in this release examine classical and selective MMP inhibitors, including specific targeting strategies for MMP-13, as well as the role of endogenous tissue inhibitors of metalloproteinases. Additional contributions explore the involvement of MMPs in various biological and disease contexts, including oral diseases, neurodegenerative disorders, neutrophil biology, and cancer progression.The volume also addresses current challenges and opportunities in the design of MMP-targeted therapeutics, highlighting advances in drug development and pharmacological applications. Together, these chapters provide valuable insights into the biochemical, physiological, and clinical significance of MMPs, making this volume an essential reference for researchers in enzymology, biochemistry, molecular biology, and biomedical sciences.Provides comprehensive reviews on matrix metalloproteinases and their biological functionsIncludes contributions from leading experts in enzymology, biochemistry, and biomedical researchCovers detection methods, regulatory mechanisms, and inhibitor design strategies for MMPsExplores the roles of MMPs in diseases including cancer, neurodegeneration, and inflammatory conditionsHighlights challenges and opportunities in developing MMP-targeted therapeutics